The yeast Saccharomyces cerevisiae is one of the most studied microorganisms, used as model system to provide crucial insights into fundamental cellular processes and human diseases at the molecular level. However, research has been largely limited to a single atypical laboratory strain.

With the ever-increasing number of sequenced genomes and natural S. cerevisiae isolates, we now aim to exploit the natural biodiversity to obtain insights on the predictability of phenotypic response from individual genomic sequences.